![]() ![]() The concern of this ~ 1000-fold dosing difference being unknowingly ingesting fentanyl contaminated “street” Norco and developing more pronounced dangerous effects than anticipated such as central nervous system (CNS) and respiratory depression. Perhaps the best way to understand the difference in potency is through differences in therapeutic dosing ranges with fentanyl being dosed in the microgram (mg) range while hydrocodone is dosed in the milligram (mg) range. Studies have shown that fentanyl binds the mu opioid receptor with about 30 times the affinity of hydrocodone. Quantifying a true difference in potency can be challenging given the multiple variables that go into such a determination including receptor affinity, receptor activation, and lipophilicity. As described above, both hydrocodone and fentanyl are opioids meaning that they are agonists at various opioid receptors. Fentanyl is termed a synthetic opioid as it is not derived from naturally occurring sources like the aforementioned opiates. Hydrocodone is considered a semi-synthetic opioid in that it is synthesized by modification of an opiate (naturally occurring compounds isolated from the Papaver somniferum poppy plant such as morphine, codeine, heroin, and opium). Legitimate Norco tablets contain a combination of acetaminophen and hydrocodone in various amounts. This report was in response to 12 cases of poisoning from “street” Norco thought to contain fentanyl over the previous 48 hours. "We spent a lot of time building credibility and acceptance which is so important when doing business in China," Mr Kelly said.On Mathe Sacramento County Division of Public Health released a drug overdose health alert entitled Fentanyl-Contaminated Street Norco. The NSW Government also worked with Norco on its market entry strategy for China. The new production facilities are also more energy efficient, producing cost savings that are re-invested in expanding the business. "It's part of our sustainable business model, so our farmers can continue to produce milk with certainty," Mr Kelly said. Increased production and storage capacity allows the business to take on greater volume. The department provided financial assistance through the Northern Rivers Jobs Plan for Norco's expansion of its Lismore factory. "We're in a niche position that allows us to service the markets between Sydney and Brisbane." Assisted by the NSW Government Mr Kelly said Norco's location on NSW's north coast is ideal for transport logistics. "Being Australian farmer-owned is a key marketing point of difference for our export customers." Mr Kelly said the integrated business model is important in giving domestic and international customers confidence in its clean and green manufactured dairy products. The co-operative is unique in that it not only processes and value-adds to its members' milk, it also services its farm base through a network of 23 rural supply stores. It manufactures ice cream as a contractor for Coles, Woolworths, Aldi and Sara Lee, and for Trader Joe's in the United States. Norco sells milk and other dairy products under the Norco brand, and in 2014 it began supplying Coles branded milk. "The fact that we are a farmers' co-operative not only appeals greatly to Australian consumers, many of whom want to see the benefits of milk production flowing back to farmers, but it is also viewed favourably in China as a guarantee of quality," Mr Kelly said. Norco already exports to the United States and Japan, and in 2014 it negotiated agreements to enter China. "It means trading in someone else's summer while its winter here," Norco Chief Executive Officer, Brett Kelly, said. An export strategy is vital for an ice cream business.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |